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KMID : 0366220090440040315
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Korean Journal of Hematology
2009 Volume.44 No. 4 p.315 ~ p.319
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Ganciclovir and Leflunomide Combination Therapy for a Patient with Cytomegalovirus Pneumonia after Unrelated Allogenic Stem Cell Transplantation
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Lim Jae-Hee
Lee Yun-Nah
Ryu Yang-Seon
Kim Han-Jo
Kim Kyoung-Ha
Kim Se-Hyung
Kim Hyun-Jung
Lee Sang-Cheol
Bae Sang-Byung
Kim Chan-Kyu
Lee Kyu-Taek
Park Sung-Kyu
Won Jong-Ho
Hong Dae-Sik
Park Hee-Sook
Park Jae-Seong
Lee You-Kyoung
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Abstract
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Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality among transplant recipients. The first line standard therapy for CMV pneumonia is treatment with a combination of ganciclovir and immunoglobulin. Nevertheless, the mortality of CMV pneumonia is 30∼70%. Leflunomide has been recently reported to have novel anti-CMV activity by inhibiting viron assembly. It is also cheaper and is more easily given orally as compared to ganciclovir. We report here on an allogenic stem cell transplant recipient who developed CMV pneumonia that was refractory to ganciclovir and immunoglobulin. The patient was successfully treated with a combination of leflunomide and ganciclovir. (Korean J Hematol 2009;44:315-319.)
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KEYWORD
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Cytomegalovirus, Ganciclovir, Leflunomide
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